The Buffalo Bills will host the Detroit Lions at Highmark Stadium for a Thursday Night Football game in Week 2

CNN

New NFL power rankings seen Sep 15 at 11:22 AM

CBS Sports

2026 Week 2 NFL score predictions, best picks today: Expert reveals exact scores for every NFL game Sep 15 at 4:33 PM

Week 3 college football picks from 10,000 simulations Sep 15 at 3:39 PM

2026 Week 2 NFL odds, start times, betting lines, spreads: Get Week 2 NFL picks, predictions for every game Sep 15 at 2:16 PM

Self-learning AI releases NFL picks, score predictions every Week 2 game Sep 15 at 2:19 PM

NFL DFS, Bills vs. Lions: Top daily Fantasy football picks, lineup advice for 'Thursday Night Football' Sep 15 at 12:06 PM

2026 Week 2 NFL picks, best bets from proven model: This 5-leg parlay pays nearly 25-1 Sep 15 at 11:32 AM

Week 2 NFL score predictions, picks: Model reveals projections from 10,000 simulations Sep 15 at 9:22 AM

Bills vs. Lions predictions, odds, time: Week 2 'Thursday Night Football' picks by proven model Sep 15 at 9:33 AM

Week 2 NFL odds, picks, predictions: Computer model backs Seahawks and Buccaneers Sep 15 at 9:19 AM

The Buffalo News

Photos: Buffalo Bills practice at Highmark Stadium ahead of home opener against Detroit Lions seen Sep 15 at 6:11 PM

The Oregonian

Bills vs. Lions: What to know about Detroit ahead of Thursday Night Football Sep 15 at 6:00 AM